14-3-3 b/a Mouse monoclonal Antibody IgG2a
Fig1: Western blot analysis on mouse liver lysates using anti-14-3-3b/a Mouse mAb (Cat. # M0407-14).
Fig2: Immunofluorescent staining of Hela cells using anti-14-3-3b/a Mouse mAb (Cat. # M0407-14).
Fig3: Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue using anti-14-3-3b/a Mouse mAb (Cat. # M0407-14).
Host Species; Species ReactivityMouse; Human, Mouse, Rat, Zebrafish
Application SummaryWB, ICC, IHC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnames14-3-3 protein beta/alpha,Protein 1054,Protein kinase C inhibitor protein 1
BackgroundThe 14-3-3 proteins are a family of proteins involved in the regulation of apoptosis, mitogenic signaling and cell-cycle checkpoints. The 14-3-3 proteins are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. Through binding Bad, 14-3-3 prevents apoptosis by sequestering Bad to the cytosol. The 14-3-3 proteins are also Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. They bind to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.(M0407-14)