β-Catenin Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis on cell lysates using anti-β-Catenin polyclonal antibody
Fig2: Western blot analysis of β-Catenin on hybrid fish (crucian-carp) heart tissue lysate using anti-β-Catenin antibody at 1/500 dilution.
Fig3: ICC staining β-Catenin (green) in Hela cells. Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat, Zebrafish
Application SummaryWB, ICC, IHC
Purification; FormulationImmunogen affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
Backgroundβ-Catenin is a multifunctional adaptor protein involved in cadherin-mediated cell–cell adhesion and in responding to the activation of several signal transduction pathways. CK1 phosphorylates β-catenin on Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37 and Thr41.). Mutations in β-Catenin have been implicated in its accumulation and various forms of carcinomas.(0407-16)