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The LinkLight™ technology is a protein-protein interaction-based functional screening cell line for biological activity. It detects compounds that not only bind to the target protein, but also activate a specific pathway.
The target protein covers cell surface receptors, including G-Protein Coupled Receptors (GPCR), Nuclear Hormone Receptors (NHR), and Receptor Tyrosine Kinases (RTK). The most common pathways for target receptors include β-arrestin and 14-3-3, and all readouts use a standard luciferase assay as the detection method.