Recombinant human MCP-3 (M.W. 8.5kDa containing 76 amino acids residues)
Human, other species not tested
MCP3, c-c motif chemokine 7, cc motif chemokine 7, monocyte chemoattractant protein 3, Nc28, CCL7, CMP3, SCYA6, SCYA7
This antibody reacts with Human MCP-3
Protein G affinity purified
0.01M PBS, pH 7.2, containing 50% glycerol
ELISA: In combination with capture antibody clone 542 (MO-C40088G), this HRP conjugated antibody can be used as tracer antibody for human MCP-3 detection in sandwich ELISA.
Store at -20°C
Horseradish peroxidase (HRP) conjugated mouse monoclonal antibody to human macrophage/monocyte chemotactic protein-3 (MCP-3)
Does not show any cross reaction with other human cytokines or growth factors tested such as IL-1β, IL-8, MCAF, SAA and EGF.
Macrophage/monocyte chemotactic protein-3 (MCP-3), like other two closely related chemokines (MCP1 and MCP-2), is chemotactic to monocytes, but not to neutrophils. MCP-3 showed 78% sequence homology with MCP-1 and 58% sequence homology with MCP-2. The primary receptor for MCP-3 is D6. MCP-3 also competes with MCP-1 to bind to CCR10, and competes with Rantes and MIP-1α to bind to CCR1. MCP-3 stimulates macrophage to secrete proteases. A variety of cancer cell lines express MCP-3, suggesting a role in tumor invasion and metastasia.