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LinkLight™ U2-OS S1PR1 / β-arrestin Cell Line is a stable monoclonal cell line in U2-OS cells, targeting Human S1PR1 pathway via b-arrestin. The proprietary LinkLight™ technology uses a standard Luciferase Assay as the detection method.
S1PR1 is similar in structure to G protein-coupled receptors, and has high expression in endothelial cells. S1PR1 binds with sphingosine-1-phosphate, with high affinity / specificity. S1PR1 is possibly involved in regulation of endothelial cell differentiation. Activation of this receptor induces cell-cell adhesion.
Host Cell Lines:
Standard Luciferase Assay System for mammalian cells should be followed according to Assay kit manufacturer protocol.