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LinkLight™ U2-OS PTH1R / β-arrestin Cell Line is a stable monoclonal cell line in U2-OS cells, targeting Human PTH1R pathway via b-arrestin. The proprietary LinkLight™ technology uses a standard Luciferase Assay as the detection method.
PTH1R acts as a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). It is a member of the G-protein coupled receptor family 2. Activity is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis.
Host Cell Lines:
Standard Luciferase Assay System for mammalian cells should be followed according to Assay kit manufacturer protocol.