Tel: 800-943-6396 Fax: 888-253-6691 Email: info@bonopusbio.com

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Bon Opus Biosciences LLC 86 Summit Ave. Suite LL300B Summit NJ 07901 USA Tel: 800-943-6396 Fax: 888-253-6691

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General Information: info@bonopusbio.com Ordering: orders@bonopusbio.com

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BC050076
2 Vials
$17,000.00
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Cat No.: 
BC050076

LinkLight™ U2-OS p38 / β-arrestin Human Kinase Cell Line

Collection: 
Product Type: 
ALTnames: 
MAPK14, hKFC-B, hkfcb, MARKK, psk2, psk 2, TAOK1, htaok1, taok 1
Packaging: 
Ship on Dry Ice
Storage: 
Liquid Nitrogen
Description: 
LinkLight™ U2-OS p38 / β-arrestin Human Kinase Cell Line is a stable monoclonal cell line in U2-OS cells, targeting Human p38 pathway via b-arrestin. The proprietary LinkLight™ technology uses a standard Luciferase Assay as the detection method.
Background: 
P38 and MAPK14 act as activators to p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases, and is involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.
5008-S
Target Protein: 
p38
Target Species: 
Human
Accession Number: 
Q7L7X3
Host Cell Lines: 
U2-OS
Assay Protocol: 
Standard Luciferase Assay System for mammalian cells should be followed according to Assay kit manufacturer protocol.