MAP2K4, MAPKK4, MAPKK 4, MEK 4, MEK4, SEK1, SEK 1, SAPKK1, SAPKK 1, JNKK, PRKMK4, SERK1
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LinkLight™ U2-OS MKK4 / 14-3-3 Human Kinase Cell Line is a stable monoclonal cell line in U2-OS cells, targeting Human MKK4 pathway via 14-3-3. The proprietary LinkLight™ technology uses a standard Luciferase Assay as the detection method.
MKK4 is a member of the Ser/Thr protein kinase family. MKK4 activates MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.
Host Cell Lines:
Standard Luciferase Assay System for mammalian cells should be followed according to Assay kit manufacturer protocol.