Tel: 800-943-6396 Fax: 888-253-6691 Email: info@bonopusbio.com

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Bon Opus Biosciences LLC 86 Summit Ave. Suite LL300B Summit NJ 07901 USA Tel: 800-943-6396 Fax: 888-253-6691

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BC050077
2 Vials
$17,000.00
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Cat No.: 
BC050077

LinkLight™ U2-OS MKK4 / 14-3-3 Human Kinase Cell Line

Collection: 
Product Type: 
ALTnames: 
MAP2K4, MAPKK4, MAPKK 4, MEK 4, MEK4, SEK1, SEK 1, SAPKK1, SAPKK 1, JNKK, PRKMK4, SERK1
Packaging: 
Ship on Dry Ice
Storage: 
Liquid Nitrogen
Description: 
LinkLight™ U2-OS MKK4 / 14-3-3 Human Kinase Cell Line is a stable monoclonal cell line in U2-OS cells, targeting Human MKK4 pathway via 14-3-3. The proprietary LinkLight™ technology uses a standard Luciferase Assay as the detection method.
Background: 
MKK4 is a member of the Ser/Thr protein kinase family. MKK4 activates MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.
5009-S
Target Protein: 
MKK4
Target Species: 
Human
Accession Number: 
P45985
Host Cell Lines: 
U2-OS
Assay Protocol: 
Standard Luciferase Assay System for mammalian cells should be followed according to Assay kit manufacturer protocol.