Tel: 800-943-6396 Fax: 888-253-6691 Email: info@bonopusbio.com

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Bon Opus Biosciences LLC 86 Summit Ave. Suite LL300B Summit NJ 07901 USA Tel: 800-943-6396 Fax: 888-253-6691

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BC050007
2 Vials
$1,500.00
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Click to view verified EC50 Data for GPR109A
Cat No.: 
BC050007

LinkLight™ U2-OS GPR109A / β-arrestin Cell Line

Collection: 
Product Type: 
ALTnames: 
HM74a, hydroxycarboxylic acid receptor 2, g protein coupled receptor 109A, GPCR 109A, Niacin receptor 1, nicontinic acid receptor, GPR109A, HCA2, NIACR1, HCAR2
Packaging: 
Ship on Dry Ice
Storage: 
Liquid Nitrogen
Description: 
LinkLight™ U2-OS GPR109A / β-arrestin Cell Line is a transiently transfected cell line in U2-OS cells, targeting Human GPR109A pathway via b-arrestin. The proprietary LinkLight™ technology uses a standard Luciferase Assay as the detection method.
Background: 
GPR109A acts as a receptor for both niacin and (D)-beta-hydroxybutyrate. Secretion of adiponectin increases lipolysis decreases through G(i)-protein-mediated inhibition of adenylyl cyclase, requiring levels of niacin that are much higher than those provided by a normal diet. It also levels niacin-induced apoptosis in mature neutrophils.
1007-T
Target Protein: 
GPR109A
Target Species: 
Human
Accession Number: 
Q8TDS4
Host Cell Lines: 
U2-OS
Assay Protocol: 
Standard Luciferase Assay System for mammalian cells should be followed according to Assay kit manufacturer protocol.