Ship on Dry Ice
LinkLight™ U2-OS FFAR3 / β-arrestin Cell Line is a transiently transfected cell line in U2-OS cells, targeting Human FFAR3 pathway via b-arrestin. The proprietary LinkLight™ technology uses a standard Luciferase Assay as the detection method.
FFAR3 acts as a receptor for short chain fatty acids. Activity is coupled to the formation of inositol 1,4,5- trisphosphate, intracellular Ca2+ mobilization, the activation of ERK 1/2 and inhibition of intracellular cAMP accumulation; coupled exclusively to the pertussis toxin-sensitive G(i/o)-alpha protein.
Host Cell Lines:
Standard Luciferase Assay System for mammalian cells should be followed according to Assay kit manufacturer protocol.