Tel: 800-943-6396 Fax: 888-253-6691 Email: info@bonopusbio.com

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Bon Opus Biosciences LLC 86 Summit Ave. Suite LL300B Summit NJ 07901 USA Tel: 800-943-6396 Fax: 888-253-6691

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BC050003
2 Vials
$17,000.00
Images: 
imagetitle: 
Click to view verified EC50 Data for CMKLR1
Cat No.: 
BC050003

LinkLight™ U2-OS CMKLR1 / β-arrestin Cell Line

Collection: 
Product Type: 
ALTnames: 
ChemR23, Chemokine like receptor 1, GPCR ChemR23, CMKLR1, DEZ
Packaging: 
Ship on Dry Ice
Storage: 
Liquid Nitrogen
Description: 
LinkLight™ U2-OS CMKLR1 / β-arrestin Cell Line is a stable monoclonal cell line in U2-OS cells, targeting Human CMKLR1 pathway via b-arrestin. The proprietary LinkLight™ technology uses a standard Luciferase Assay as the detection method.
Background: 
CMKLR1 (ChemR23) is a G-protein coupled receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. ChemR23 functions as a coreceptor for SIV and some primary HIV-1 strains.
1003-S
Target Protein: 
CMKLR1
Target Species: 
Human
Accession Number: 
Q99788
Host Cell Lines: 
U2-OS
Assay Protocol: 
Standard Luciferase Assay System for mammalian cells should be followed according to Assay kit manufacturer protocol.