C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin chemotactic receptor, C5a-R, C5aR, CD88
LinkLight™ U2-OS C5AR1 / β-arrestin Cell Line is a stable monoclonal cell line in U2-OS cells, targeting Human C5AR1 pathway via b-arrestin. The proprietary LinkLight™ technology uses a standard Luciferase Assay as the detection method.
C5AR1 is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events.
Host Cell Lines:
U2OS (ATCC number HTB-96) Osteosarcoma; Bone sarcoma from the tibia of a human female.
Standard Luciferase Assay System for mammalian cells should be followed according to Assay kit manufacturer protocol.