Tel: 800-943-6396 Fax: 888-253-6691 Email: info@bonopusbio.com

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Bon Opus Biosciences LLC 86 Summit Ave. Suite LL300B Summit NJ 07901 USA Tel: 800-943-6396 Fax: 888-253-6691

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BC050087
2 Vials
$17,000.00
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Cat No.: 
BC050087

LinkLight™ U2-OS BTK / β-arrestin Human Kinase Cell Line

Collection: 
Product Type: 
ALTnames: 
Tyrosine-protein kinase, Agammaglobulinemia tyrosine kinase, ATK, B-cell progenitor kinase, BTK, BPK, Bruton tyrosine kinase, AGMX1
Packaging: 
Ship on Dry Ice
Storage: 
Liquid Nitrogen
Description: 
LinkLight™ U2-OS BTK / β-arrestin Human Kinase Cell Line is a Stable monoclonal cell line in U2-OS cells, targeting Human BTK pathway via Human Kinase LinkLight™ Assay Cells. The proprietary LinkLight™ technology uses a standard Luciferase Assay as the detection method.
Background: 
BTK, also known as Bruton’s Tyrosine Kinase, is a non-receptor tyrosine kinase for B lymphocyte development, differentiation, and signaling. The binding of an antigen to the B-cell antigen receptor (BCR) triggers signaling leading to the activation of the B-cell. Once the BCR is engaged, PLCG2 phosphorylates at several sites, initiating signaling pathway through calcium mobilization, and then activates protein kinase C (PKC) family members. Phosphorylation of PLCG2 performs in tangent with the adapter protein B-cell linker protein BLNK. BTK also works to gather diverse signaling proteins and is implicated in cytokine receptor signaling pathways, as well as function of immune cells of innate as well as adaptive immunity, as part of the Toll-like receptor (TLR) pathway. BTK is involved with signaling pathways that link TLR8/9 to NF-kappa-B. BTK is also needed in order to form functional ARID3A DNA-binding complexes.
Target Protein: 
BTK
Target Species: 
Human
Accession Number: 
Q06187
Host Cell Lines: 
U2-OS
Assay Protocol: 
Standard Luciferase Assay System for mammalian cells should be followed according to Assay kit manufacturer protocol.
Datasheet: 
Cell Line Datasheet
BC050087 Product Booklet