β2AR, Beta-2 adrenergic receptor, Beta-2 adrenoreceptor, ADRB2, ADRB2R, B2AR
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LinkLight™ HEK293 ADRB2 GPCR/14-3-3 Cell Line is a stable monoclonal cell line in HEK293 cells, targeting Human ADRB2 pathway via 14-3-3. The proprietary LinkLight™ technology uses a standard Luciferase Assay as the detection method.
ADRB2 is a member of the G protein-coupled receptor superfamily. ADRB2 is directly associated with the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. This gene is intronless, and different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
Host Cell Lines:
Standard Luciferase Assay System for mammalian cells should be followed according to Assay kit manufacturer protocol.