Tel: 800-943-6396 Fax: 888-253-6691 Email: info@bonopusbio.com

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Bon Opus Biosciences LLC 86 Summit Ave. Suite LL300B Summit NJ 07901 USA Tel: 800-943-6396 Fax: 888-253-6691

Emails:

General Information: info@bonopusbio.com Ordering: orders@bonopusbio.com

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BC050085
2 vials
$1,500.00
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HepG2 PXR / 3A4-Luciferase Cell Line

Cat No.: 
BC050085
Collection: 
Product Type: 
ALTnames: 
PAR1, PXR, SXR, Nuclear Receptor Subfamily 1 Group I member 2, Steroid and xenobiotic receptor
Packaging: 
Ship on Dry Ice
Storage: 
Liquid Nitrogen
Description: 
HepG2 PXR / 3A4-Luciferase Cell Lines is a Transiently transfected cell line in HepG2 cells, targeting the PXR pathway via 3A4-Luciferase Assay cells, and uses a standard Luciferase Assay as the detection method.
Background: 
GXR, also known as Pregnane X receptor, is a nuclear receptor binding with, and activated by, a variety of endogenous and xenobiotic compounds. GXR acts as a transcription factor that activates transcription of genes involved in metabolism and secretion of xenobiotics, drugs and endogenous compounds, and is activated by the antibiotic rifampicin and various plant metabolites or naturally occurring steroids, such as pregnenolone and progesterone. GXR has species-specific responses to ligands, and binds to promoters of the CYP3A4 and ABCB1/MDR1 genes.
4201-T
Target Protein: 
PXR
Target Species: 
Human
Accession Number: 
O75469
Host Cell Lines: 
HepG2
Assay Protocol: 
Standard Luciferase Assay System for mammalian cells should be followed according to Assay kit manufacturer protocol.
Datasheet: 
Cell Line Datasheet
BC050085 Product Booklet